Thermo Fisher Scientific alpha Actinin 4 Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit polyclonal 항체로 Western blot, IHC, ICC/IF에 사용 가능. Recombinant alpha Actinin 4(aa 698–911)로부터 생성된 비결합형 항체. 항원 친화 크로마토그래피로 정제되었으며, 0.32 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific alpha Actinin 4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 698–911 of Human alpha Actinin 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.32 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544951 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, A375, Neuro 2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, mouse brain, PC-12
- Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (85%), Xenopus laevis (92%), Chicken (94%), Rhesus Monkey (100%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Alpha actinins belong to the spectrin gene superfamily, a diverse group of cytoskeletal proteins including alpha and beta spectrins and dystrophins.
Alpha actinin is an actin-binding protein with multiple roles in different cell types:
- In nonmuscle cells, it is found along microfilament bundles and adherens-type junctions, binding actin to the membrane.
- In muscle cells, it localizes to the Z-disc and dense bodies, anchoring myofibrillar actin filaments.
This gene encodes a nonmuscle isoform concentrated in the cytoplasm and is thought to be involved in metastatic processes.
Mutations have been associated with focal and segmental glomerulosclerosis.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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