Thermo Fisher Scientific CD8A (Cytotoxic/Suppressor T-Cell Marker) Monoclonal Antibody (RIV11)

Applications

Immunocytochemistry (ICC/IF)

• Tested dilution: 1–2 µg/mL

Flow Cytometry (Flow)

• Tested dilution: 1–2 µg/10⁶ cells

Product Specifications

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family that plays an integral role in signal transduction, T cell differentiation, and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
In contrast, CD4 acts as a co-receptor for MHC class II molecules. CD8 can also exist as a homodimer of CD8α on subsets of T cells, NK cells, monocytes, and dendritic cells.
Engagement of MHC-I/peptide complexes by CD8 triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs play a key role in eliminating pathogens and tumor cells. Differentiation of naïve CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.