Thermo Fisher Scientific CDK7 Monoclonal Antibody (3E3)

Applications

Tested Dilution

Publications

Western Blot (WB)

0.2 - 0.4 µg/mL

-

Immunocytochemistry (ICC/IF)

5 µg/mL

-

ELISA (ELISA)

Assay-dependent

-

Immunoprecipitation (IP)

2 µg

-

Product Specifications

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

3E3

Immunogen

Recombinant human protein purified from E.coli(His/ABD-CDK7 136-346 a.a.) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDK7,uniProtId:P50613-1,ncbiNodeId:9606,antigenRange:136-346,antigenLength:346,antigenImageFileName:MA5-17209_CDK7_P50613-1_House_mouse.svg,antigenImageFileNamePDP:MA5-17209_CDK7_P50613-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2538677

Product Specific Information

A suggested positive control for this product is HeLa cells.

Target Information

The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). CDK7 may be a target of germline cancer-inducing mutations.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.