Thermo Fisher Scientific Human TEM7 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the center of human TEM7.
PEP-0545 can be used as a blocking peptide with polyclonal antibody PA5-20428.

Target Information

Using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al. identified 46 genes with elevated expression in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC) and named as Tumor Endothelial Markers (TEMs, TEM1–9).
TEM7 (Tumor Endothelial Marker 7) transcripts are specifically expressed in the endothelium of colorectal, lung, pancreas, breast, and brain cancers, both in primary and metastatic tissues. Other members of this family (TEM1, 3, 4, 5, 8, and 9) show similar expression patterns in lung and brain tumors and liver metastasis.
As many genes differentially expressed in tumor endothelium are also active during angiogenesis, these newly discovered genes provide valuable resources for basic and clinical studies of human angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.