Thermo Fisher Scientific Phospho-PLCG2 (Tyr1217) Polyclonal Antibody
Phospho-PLCG2 (Tyr1217) 폴리클로날 항체로 인간, 마우스, 랫트 시료에서 사용 가능. Western blot에 적합하며, PLCγ1 인산화형과 교차반응 없음. 항원 친화 크로마토그래피로 정제된 고순도 액상 항체. 연구용으로만 사용.
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- PA517700
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Thermo Fisher Scientific Phospho-PLCG2 (Tyr1217) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr1217 of human PLCγ2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 64 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987420 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with phosphorylated PLCγ1.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction through the generation of two second messengers: inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Mammalian PLC isozymes include PLCβ1, PLCβ2, PLCβ3, PLCβ4, PLCγ1, PLCγ2, PLCδ1, PLCδ2, and PLCε.
PLCδ exists as four isoforms. PLCδ1, a calcium signal amplifier, is activated by an atypical GTP-binding protein and acts as an effector for transglutaminase II-mediated oxytocin receptor and α1B-adrenoreceptor signaling. Mouse PLCδ1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLCδ in Alzheimer’s disease brains suggests its role in AD pathology. PLCδ2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, and its expression may serve as a marker of gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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