Thermo Fisher Scientific Phospho-PLCG2 (Tyr1217) Polyclonal Antibody

Thermo Fisher Scientific Phospho-PLCG2 (Tyr1217) Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:1,000
Publications: - References

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with phosphorylated PLCγ1.

Target Information

Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction through the generation of two second messengers: inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Mammalian PLC isozymes include PLCβ1, PLCβ2, PLCβ3, PLCβ4, PLCγ1, PLCγ2, PLCδ1, PLCδ2, and PLCε.

PLCδ exists as four isoforms. PLCδ1, a calcium signal amplifier, is activated by an atypical GTP-binding protein and acts as an effector for transglutaminase II-mediated oxytocin receptor and α1B-adrenoreceptor signaling. Mouse PLCδ1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLCδ in Alzheimer’s disease brains suggests its role in AD pathology. PLCδ2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, and its expression may serve as a marker of gastric malignant transformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.