Thermo Fisher Scientific CD85j (ILT2) Monoclonal Antibody (GHI/75)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody recognizes an extracellular epitope of CD85j / ILT2, an 110–120 kDa membrane glycoprotein expressed strongly on plasma cells, moderately on circulating B cells, and weakly on monocytes. It is also expressed on T cell and NK cell subsets, with variable expression among individuals.

Target Information

The CD85j (ILT2) gene belongs to the leukocyte immunoglobulin-like receptor (LIR) family located in the chromosomal region 19q13.4. The encoded protein is part of the LIR subfamily B class, containing two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
It is expressed on immune cells, binds MHC class I molecules on antigen-presenting cells, and transduces inhibitory signals that modulate immune responses. This receptor helps regulate inflammation and cytotoxicity to maintain immune balance and prevent autoreactivity. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.