Thermo Fisher Scientific Phospho-MDM2 (Thr218) Polyclonal Antibody

Applications

• Dot blot (DB)

Tested Dilution: 1:500
Publications: -

Product Specifications

Target Information

MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53. MDM2 is located on chromosome 12 on the q arm. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.
MDM2 negatively regulates p53 function by inhibiting transactivation and promoting degradation through its E3 ubiquitin ligase activity. It also plays roles in apoptosis and cell cycle regulation. Overexpression of MDM2 is observed in various human malignancies such as soft tissue carcinomas and breast cancer.
In addition to p53, MDM2 interacts with proteins including retinoblastoma 1 and ribosomal protein L5. More than 40 alternatively spliced transcript variants of MDM2 have been identified in both tumor and normal tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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