Thermo Fisher Scientific Phospho-E2F1 (Ser332) Polyclonal Antibody
Human E2F1 단백질의 Ser332 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Dot blot에 적합하며, Protein A 및 Antigen affinity chromatography로 정제됨. PBS buffer에 보관하며, 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-E2F1 (Ser332) Polyclonal Antibody
Applications
- Dot blot (DB)
Tested Dilution: 1:500
Publications: - (참조 없음)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S332 of human E2F1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981508 |
Target Information
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and the action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.
E2F proteins contain conserved domains including:
- DNA binding domain
- Dimerization domain (interacts with DP proteins)
- Transactivation domain enriched in acidic amino acids
- Tumor suppressor protein association domain (within transactivation domain)
E2F1, along with E2F2 and E2F3, possesses an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner and can mediate both cell proliferation and p53-dependent/independent apoptosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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