Thermo Fisher Scientific ICAM-1 Monoclonal Antibody (1H4), APC

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 정보 없음
• View 2 publications

Flow Cytometry (Flow)

• Tested Dilution: 10 µL/1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 700
• Biotin
• FITC
• PE
• PerCP
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes an extracellular epitope of CD54 (ICAM-1), an 85–110 kDa type I transmembrane glycoprotein that acts as a receptor for rhinovirus. It is expressed on activated endothelial cells, T and B lymphocytes, monocytes, macrophages, granulocytes, and dendritic cells. Expression is upregulated upon activation.

Target Information

ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein composed of five immunoglobulin-like domains, a transmembrane region, and a cytoplasmic domain. It has seven potential N-linked glycosylation sites and shares sequence homology with ICAM-2 and ICAM-3. ICAM-1 interacts with integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and serves as a receptor for rhinovirus. It is expressed on activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, lymphocytes, monocytes, macrophages, dendritic cells, and neutrophils, with expression increasing during inflammation. Soluble ICAM-1 is detectable in plasma and elevated in inflammatory conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지