Thermo Fisher Scientific CD7 Monoclonal Antibody (MEM-186), PE

Applications

• Flow Cytometry (Flow): 20 µL / 1×10⁶ cells

Product Specifications

Available Formats

• Unconjugated
• APC
• FITC
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD7, a 40 kDa type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK cells, hematopoietic progenitors, monocytes (weakly), and also on acute lymphocytic leukemia.

Target Information

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. The N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains, while the C-terminal region is proline-rich and forms a stalk projecting the Ig domain. CD7 is expressed on most immature and mature T-lymphocytes, T cell leukemia, NK cells, a small subset of normal B cells, and malignant B cells. Cross-linking surface CD7 modulates T cell and NK cell activity, influencing calcium fluxes, adhesion molecule expression, cytokine secretion, and proliferation. CD7 associates directly with phosphoinositol 3-kinase, and its ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. CD7 expression is an important marker in leukemia diagnostics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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