Thermo Fisher Scientific Phospho-JAK3 (Tyr904) Polyclonal Antibody
JAK3의 Tyr904 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며, 인간, 마우스, 랫트 시료에서 반응. PBS/glycerol buffer에 보관하며 -20°C에서 안정적 보존 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK3 (Accession P52333), corresponding to amino acid residues around phosphorylated Tyr904 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817290 |
Product Specific Information
Antibody detects endogenous levels of JAK3 only when phosphorylated at Tyr904.
Target Information
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and mediates signaling in response to activation of interleukin receptors. Upon stimulation by cytokines or related factors (e.g., interferons, interleukins), JAKs are activated via phosphorylation at adjacent tyrosine residues. Activated JAKs phosphorylate STAT proteins, which then dimerize and translocate to the nucleus to regulate transcription of numerous genes, including interferon-stimulated genes. JAK2 is essential for IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier. Some studies suggest that Tyk2 and JAK3 may substitute for JAK2 if positioned appropriately within the receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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