Thermo Fisher Scientific Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody
LATS1/LATS2 단백질의 Ser909/Ser872 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC(파라핀 절편)에 적합. 사람, 마우스, 랫트 반응성. PBS/glycerol 용액 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LATS1 (Accession O95835), corresponding to amino acid residues around phosphorylated Ser872 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817294 |
Product Specific Information
Antibody detects endogenous levels of LATS1/2 only when phosphorylated at Ser909/872.
Target Information
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region binds CDC2 to form a complex showing reduced H1 histone kinase activity, acting as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor, supported by knockout mouse studies showing development of soft-tissue sarcomas, ovarian stromal cell tumors, and high sensitivity to carcinogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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