Thermo Fisher Scientific Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody
LATS1/LATS2 단백질의 Ser909/Ser872 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC(파라핀 절편)에 적합. 사람, 마우스, 랫트 반응성. PBS/glycerol 용액 형태로 -20°C 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LATS1 (Accession O95835), corresponding to amino acid residues around phosphorylated Ser872 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817294 |
Product Specific Information
Antibody detects endogenous levels of LATS1/2 only when phosphorylated at Ser909/872.
Target Information
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region binds CDC2 to form a complex showing reduced H1 histone kinase activity, acting as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor, supported by knockout mouse studies showing development of soft-tissue sarcomas, ovarian stromal cell tumors, and high sensitivity to carcinogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.