Thermo Fisher Scientific Phospho-JAK2/JAK3 (Tyr966, Tyr939) Polyclonal Antibody
JAK2/JAK3의 Tyr966/939 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에 적합하며, 고순도 액상 형태로 제공. 인간, 마우스, 랫트 반응성. 연구용 전용 제품.
- 카탈로그번호
- PA5105890
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK2 (Accession O60674), corresponding to amino acid residues around phosphorylated Tyr966 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817289 |
Product Specific Information
Antibody detects endogenous levels of JAK2/3 only when phosphorylated at Tyr966/939.
Target Information
Janus Activating Kinase 2 and 3 (JAK2/JAK3) are tyrosine kinases involved in cytoplasmic signal transduction. Upon stimulation by cytokines or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at adjacent tyrosine residues. Activated JAKs phosphorylate STAT proteins, which dimerize and translocate to the nucleus to regulate transcription of numerous genes, including interferon-stimulated genes.
JAK2 is essential for IFN gamma-receptor complex initiation, while JAK1 functions as an amplifier. Active JAK1 may be required for complex responses. Some studies suggest that JAK2’s role might be substituted by Tyk2 and JAK3 if correctly positioned within the IFN gamma-receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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