Thermo Fisher Scientific Phospho-ATF4 (Ser224) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of ATF4 only when phosphorylated at Ser224.

Target Information

This gene encodes a transcription factor originally identified as a widely expressed mammalian DNA-binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1.
The encoded protein was also characterized as the cAMP-response element binding protein 2 (CREB-2).
It belongs to a family of DNA-binding proteins including AP-1, CREBs, and CREB-like proteins.
These transcription factors share a leucine zipper region involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids functioning as a DNA-binding domain.
Two alternative transcripts encoding the same protein have been described.
Two pseudogenes are located on the X chromosome at q28 within a region containing a large inverted duplication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.