Thermo Fisher Scientific IL-6 Polyclonal Antibody
말 항원 특이적 IL-6 폴리클로날 항체로 WB, ICC/IF, 중화 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공. 다양한 종 IL-6과 교차반응을 보이며, 염증 관련 연구에 유용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
| Neutralization (Neu) | 0.5–1.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant equine IL-6 (Phe26–Met208) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606214 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant human IL-6, recombinant porcine IL-6, and recombinant canine IL-6 is observed.
- Approximately 20% cross-reactivity with recombinant mouse IL-6 and recombinant rat IL-6.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Interleukin-6 (IL-6) encodes a cytokine involved in inflammation and B cell maturation. The IL-6 protein acts as an endogenous pyrogen, inducing fever in autoimmune diseases or infections. It is primarily expressed at sites of acute and chronic inflammation, secreted into serum, and induces inflammatory gene transcription via the IL-6 receptor alpha.
IL-6 function is implicated in various inflammation-associated diseases, including susceptibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated IL-6 levels have been reported in viral infections such as COVID-19 (SARS-CoV-2 infection). Diseases associated with IL-6 include Kaposi Sarcoma and Systemic Juvenile Rheumatoid Arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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