Thermo Fisher Scientific HTR2C Polyclonal Antibody
HTR2C 폴리클로날 항체로 인간 시료에 반응하며, 면역조직화학(IHC) 검증 완료. 합성 펩타이드 면역원 기반으로 제작되어 높은 특이성과 재현성 제공. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 연구용에 적합.
- 카탈로그번호
- PA533306
- 판매단위
- pk
카탈로그
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution
- 5.6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human 5HT2C Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550690 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Marmoset (100%)
- Monkey (95%)
- Elephant, Panda, Horse (80%)
Target Information
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that exerts diverse physiological effects through multiple receptor subtypes, including the 5-HT2 family of seven-transmembrane G-protein-coupled receptors. These receptors activate phospholipase C and D signaling pathways.
The gene encoding the 5-HT2C receptor undergoes multiple RNA editing events, converting adenosine to inosine, which alters amino acids in the second intracellular loop. This generates receptor isoforms with differing G-protein interaction and signaling activity, modulating serotonergic neurotransmission in the central nervous system. Abnormal RNA editing patterns of 5-HT2C have been reported in depressed suicide victims.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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