Thermo Fisher Scientific HTR2C Polyclonal Antibody

Applications

Tested Application

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution

• 5.6 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Marmoset (100%)
• Monkey (95%)
• Elephant, Panda, Horse (80%)

Target Information

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that exerts diverse physiological effects through multiple receptor subtypes, including the 5-HT2 family of seven-transmembrane G-protein-coupled receptors. These receptors activate phospholipase C and D signaling pathways.

The gene encoding the 5-HT2C receptor undergoes multiple RNA editing events, converting adenosine to inosine, which alters amino acids in the second intracellular loop. This generates receptor isoforms with differing G-protein interaction and signaling activity, modulating serotonergic neurotransmission in the central nervous system. Abnormal RNA editing patterns of 5-HT2C have been reported in depressed suicide victims.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.