Thermo Fisher Scientific HTR2C Polyclonal Antibody

Thermo Fisher Scientific HTR2C Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 2.6 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant (100%)
Horse, Pig (94%)

Target Information

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that elicits a wide range of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of G-protein-coupled receptors. These receptors activate phospholipase C and D signaling pathways.
The HTR2C gene encodes the 2C subtype of serotonin receptor, whose mRNA undergoes multiple RNA editing events converting adenosine residues to inosines. This editing alters amino acids within the second intracellular loop, generating receptor isoforms with differing G-protein interactions and signaling capabilities, thereby modulating serotonergic neurotransmission in the CNS.
Studies have shown abnormal 5-HT2C editing patterns in depressed suicide victims.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.