Thermo Fisher Scientific HTR2C Polyclonal Antibody
HTR2C 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 및 비인간 영장류에 반응합니다. IHC(Paraffin)에서 2.6 µg/mL 농도로 사용 가능하며, 항원 친화 크로마토그래피로 정제된 고품질 항체입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific HTR2C Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 2.6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5HT2C Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550691 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant (100%)
Horse, Pig (94%)
Target Information
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that elicits a wide range of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of G-protein-coupled receptors. These receptors activate phospholipase C and D signaling pathways.
The HTR2C gene encodes the 2C subtype of serotonin receptor, whose mRNA undergoes multiple RNA editing events converting adenosine residues to inosines. This editing alters amino acids within the second intracellular loop, generating receptor isoforms with differing G-protein interactions and signaling capabilities, thereby modulating serotonergic neurotransmission in the CNS.
Studies have shown abnormal 5-HT2C editing patterns in depressed suicide victims.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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