Thermo Fisher Scientific Phospho-BRCA1 (Ser1524) Polyclonal Antibody
BRCA1 단백질의 Ser1524 인산화 부위를 인식하는 폴리클로날 항체. Western blot 및 IHC(Paraffin)에서 검증됨. 인간, 마우스, 랫트에 반응하며, 고순도(>95%) 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Serine 1524 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553623 |
Product Specific Information
- Detects endogenous protein at a molecular weight of approximately 200 kDa.
- Purity >95% by SDS-PAGE.
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein involved in maintaining genomic stability and acts as a tumor suppressor. It forms part of the BASC (BRCA1 associated genome surveillance complex) and associates with RNA polymerase II and histone deacetylase complex. BRCA1 plays a critical role in transcription, DNA repair of double-stranded breaks, and recombination.
Mutations in BRCA1 account for around 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing influences subcellular localization and function, and multiple transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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