Thermo Fisher Scientific IL18BP Monoclonal Antibody (7A11C11G1)

Applications

ELISA

• Tested Dilution: 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human IL18BPa.

Target Information

Interleukin-18 binding protein (IL-18BP) is a constitutively secreted glycoprotein that acts as a natural antagonist for interleukin-18 (IL-18) by preventing interaction between IL-18 and its receptors. Through this binding, IL-18BP neutralizes the proinflammatory role of IL-18 in cell-mediated immune responses, resulting in reduced IFN-gamma production by T helper type I cells and inhibition of allospecific cytotoxic T lymphocyte (CTL) activity through augmented natural killer (NK) cell cytotoxicity.

As an inhibitor of IL-18 and an essential component of skin homeostasis, IL-18BP has been linked to various diseases, including eczema, asthma, and Crohn’s disease. The upregulation of IL-18BP by keratinocytes expressing the human papillomavirus (HPV) E7 oncoprotein has been shown to decrease IL-18-induced IFN-gamma production and IL-18-mediated T cell activation. Elevated levels of IL-18 and IL-18BP, as well as proinflammatory cytokines IFN-gamma, TNF-alpha, IL-1beta, and IL-8, have been linked to chronic inflammation observed in macrophages (including Kupffer cells) from Crohn’s disease lesions and intestinal tissues.

IL-18BP, a member of the immunoglobulin-like receptor class, contains a single immunoglobulin (Ig) domain. Two of the four identified human isoforms (b and d) contain incomplete domains that greatly reduce their binding affinity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.