Thermo Fisher Scientific SHP2 Polyclonal Antibody
SHP2 단백질을 인식하는 Thermo Fisher Scientific의 다클론성 항체로, WB, ICC/IF, Flow Cytometry에 사용 가능. Human, Mouse, Rat 반응성. Rabbit IgG 기반, Lyophilized 형태. 세포 신호 조절 연구 및 Noonan 증후군 관련 연구에 적합.
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Thermo Fisher Scientific SHP2 Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human SHP2 (582–597aa RVYENVGLMQQQKSFR). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2806875 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family.
PTPs are signaling molecules that regulate various cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate interactions with substrates.
It is widely expressed in most tissues and plays a regulatory role in cell signaling events important for mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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