Thermo Fisher Scientific PDE3B Monoclonal Antibody (SMCP3B), eBioscience
마우스 PDE3B 단백질을 특이적으로 인식하는 단클론 항체로, 웨스턴 블롯(WB)에 적합합니다. Rat IgG2a 아이소타입이며 비결합형(Unconjugated) 형태입니다. 고순도(>90%)로 정제되었으며 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
- Application: Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SMCP3B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1603298 |
Product Specific Information
Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP, regulating the effects of these second messengers. The PDE3 family includes two members, PDE3A and PDE3B, encoded by separate genes. PDE3B (~130 kDa) is mainly expressed in adipose tissue and lymphocytes, while PDE3A (~120 kDa) is expressed predominantly in platelets and heart tissue.
The monoclonal antibody SMCP3B reacts specifically with mouse PDE3B. It was generated against amino acids 643–1100 in the C-terminus and does not cross-react with mouse PDE3A, as confirmed by western blot analysis of mouse heart lysates. It also does not cross-react with human PDE3B.
- Applications Reported: Immunoblotting (WB)
- Applications Tested: Tested by immunoblotting of mouse lymph node cells and mouse heart under reducing conditions. Recommended dilution is 1–5 µg/mL. Optimal titration is advised for best results.
- Purity: >90% (SDS-PAGE)
- Aggregation: <10% (HPLC)
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
Cyclic nucleotide phosphodiesterase with dual specificity for cAMP and cGMP, key regulators of many physiological processes. PDE3B may play a role in fat metabolism and regulates cAMP binding of RAPGEF3. It forms a signaling complex with RAPGEF3 and PIK3R6, activating the PI3K gamma complex involved in angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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