Thermo Fisher Scientific IFN gamma Monoclonal Antibody (G-23)
인간 IFN-γ를 인식하는 마우스 단클론 항체로, WB, Flow Cytometry, ELISA에 사용 가능. 단백질 A로 정제된 액상 형태이며, 4°C 보관. 면역 활성 연구 및 사이토카인 분석에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IFN gamma Monoclonal Antibody (G-23)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | 2–4 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G-23 |
| Immunogen | Recombinant human IFN-gamma (aa 22–166 representing mature IFN-gamma) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075720 |
Product Specific Information
This antibody reacts with IFN-gamma, a 16–25 kDa cytokine produced by activated Th1 cells and NK cells.
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, and cytokines.
It is a dimeric glycoprotein (~45 kDa) composed of two 146 amino acid subunits. On SDS-PAGE, IFN gamma appears as 25, 20, and minor 15.5 kDa bands due to differential glycosylation.
The biological activity of IFN gamma is highly species-specific, with no cross-reactivity between human and mouse.
Functions include:
- Antiviral and tumor antiproliferative activity
- Induction of class I and II MHC
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
IFN gamma acts through the JAK-STAT pathway upon binding to IFN gamma receptors I and II.
It shares ~40% sequence homology between human and mouse and is regulated by IL-2, FGF basic, and EGF, while downregulated by vitamin D3 or DMN.
Mutations in the IFN gamma gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.