Thermo Fisher Scientific Phospho-FOXO4 (Thr451) Polyclonal Antibody
FOXO4 단백질의 Thr451 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 고순도 액상 형태로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FOXO4 (Accession P98177), corresponding to amino acid residues around phosphorylated Thr451 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816417 |
Product Specific Information
This antibody detects endogenous levels of FOXO4 only when phosphorylated at Threonine 451.
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. Also known as AFX1 or MLLT7, it belongs to the O class of forkhead/winged helix transcription factors along with FOXO1, FOXO3, and FOXO6.
FOXO4 is highly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Activation of the Insulin/IGF1 pathway via Akt leads to phosphorylation of FOXO4 on specific Ser/Thr residues, promoting binding to 14-3-3 and nuclear export.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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