Thermo Fisher Scientific IKK epsilon Recombinant Rabbit Monoclonal Antibody (JU06-72)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed to select the best-producing clones.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

IKBKE (IKK epsilon) is an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death.
NF-κB is a key transcription factor involved in immune and inflammatory responses, regulating gene expression in response to extracellular stimuli.
IKK epsilon is part of the IKK complex and is required for NF-κB activation by PMA and T cell receptors but not by TNF-α and IL-1. IKK-iota/IKK-i expression is inducible by TNF-α, IL-1, and LPS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.