Thermo Fisher Scientific CD49d (Integrin alpha 4) Polyclonal Antibody
Rabbit polyclonal antibody against human CD49d (Integrin alpha 4). Validated for WB and ELISA. Recognizes membrane protein expressed in Jurkat cells. Supplied as liquid, affinity purified, stored in PBS with glycerol. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 770–970 of human Integrin alpha 4 (ITGA4/CD49d) (NP_0008763) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.38 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804192 |
Product Specific Information
Immunogen sequence:
LKYEVKLTVH GFVNPTSFVY GSNDENEPET CMVEKMNLTF HVINTGNSMA PNVSVEIMVP NSFSPQTDKL FNILDVQTTT GECHFENYQR VCALEQQKSA MQTLKGIVRF LSKTDKRLLY CIKADPHCLN FLCNFGKMES GKEASVHIQL EGRPSILEMD ETSALKFEIR ATGFPEPNPR VIELNKDENV AHVLLEGLHH Q
Positive Samples: Jurkat
Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. The alpha4 chain associates with either beta1 or beta7 chain. Ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 are located on the alpha4 chain. Ligands include MadCAM, VCAM, and fibronectin. MadCAM is the principal ligand for integrin alpha4beta7. HIV-1 envelope can mimic MadCAM by binding to and signaling through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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