Thermo Fisher Scientific DDX1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DDX1 protein. Validated for WB, IHC, IHC-P, and IP applications. Antigen affinity purified, supplied as liquid at 0.2 mg/mL. Recommended storage at 4°C. Predicted cross-reactivity with mouse, rat, bovine, and ...
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Thermo Fisher Scientific DDX1 Polyclonal Antibody
Applications and Recommended Dilutions
| Application | Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 500 and 550 of human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, predicted to react with mouse, rat, bovine, and orangutan
Target Information
DDX1 (ATP-dependent RNA helicase DDX1) functions as an ATP-dependent RNA helicase capable of unwinding both RNA-RNA and RNA-DNA duplexes. It exhibits single-stranded RNA overhang nuclease and ATPase activities on RNA substrates. DDX1 acts as a coactivator with RELA to enhance NF-κB-mediated transcriptional activation and positively regulates cyclin CCND2 expression by binding to its promoter region. It is also part of a multi-helicase-TICAM1 complex serving as a cytoplasmic sensor of viral double-stranded RNA, initiating antiviral responses and proinflammatory cytokine induction via TICAM1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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