Thermo Fisher Scientific SHANK1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to the N-terminal residues E(63) R L L R E Y P Q S F E K G V(77) of rat Shank1a. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SHANK1,uniProtId:Q9WV48-1,ncbiNodeId:10114,antigenRange:63-77,antigenLength:2167,antigenImageFileName:PA1-4179_SHANK1_Q9WV48-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4179_SHANK1_Q9WV48-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2285898

Product Specific Information

PA1-4179 detects SHANK1a in rat samples.

PA1-4179 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~212 kDa protein representing SHANK1a in rat brain lysate.

The PA1-4179 immunogen is a synthetic peptide corresponding to the N-terminal residues E(63) R L L R E Y P Q S F E K G V(77) of rat Shank1a.

Target Information

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.