Thermo Fisher Scientific AMBRA1 Polyclonal Antibody
AMBRA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA에 사용 가능. 인간 및 설치류 반응성, 고순도 Affinity Chromatography 정제, -20°C 보관. 세포 내 자가포식 관련 연구에 적합.
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Thermo Fisher Scientific AMBRA1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1109–1208 of human Ambra1 (NP_060219.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.87 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804619 |
Product Specific Information
- Positive Samples: U-87MG, HeLa, Jurkat, MCF7
- Cellular Location: Cytoplasmic vesicle, autophagosome
- Immunogen Sequence:
GAAHTSSPQP STSRGLLPEA GQLAERGLSP RTASWDQPGT PGREPTQPTL PSSSPVPIPV SLPSAEGPTL HCELTNNNHL LDGGSSRGDA AGPRGEPRNR
Target Information
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. It helps preserve cellular nutrients under starvation and supports normal turnover of cytosolic components.
Beclin-1, a principal regulator of autophagosome formation, is regulated by Ambra1, which associates with Beclin-1 through a central region identified by yeast two-hybrid assay.
Null mutations in Ambra1 lead to embryonic lethality with neural tube defects and impaired autophagy. Down-regulation of Ambra1 decreases rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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