Thermo Fisher Scientific SDHB Polyclonal Antibody
Thermo Fisher Scientific의 SDHB Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 WB, ICC/IF, ELISA에 사용 가능. 미토콘드리아 내막의 SDHB 단백질 검출용으로 높은 특이성과 감도를 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 29–280 of human SDHB (NP_0029912) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.82 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804617 |
Product Specific Information
Immunogen sequence:
AQTAAATAPR IKKFAIYRWD PDKAGDKPHM QTYEVDLNKC GPMVLDALIK IKNEVDSTLT FRRSCREGIC GSCAMNINGG NTLACTRRID TNLNKVSKIY PLPHMYVIKD LVPDLSNFYA QYKSIEPYLK KKDESQEGKQ QYLQSIEERE KLDGLYECIL CACCSTSCPS YWWNGDKYLG PAVLMQAYRW MIDSRDDFTE ERLAKLQDPF SLYRCHTIMN CTRTCPKGLN PGKAIAEIKK MMATYKEKKA SV
Positive Samples: HepG2, HeLa, U-87MG, Mouse brain, Mouse liver, Mouse kidney, Mouse heart, Rat liver, Rat brain
Cellular Location: Matrix side, Mitochondrion inner membrane, Peripheral membrane protein
Target Information
Complex II of the respiratory chain is involved in the oxidation of succinate and electron transfer from FADH to CoQ. It consists of four nuclear-encoded subunits located in the mitochondrial inner membrane. The iron-sulfur subunit contains three cysteine-rich clusters forming the enzyme’s iron-sulfur centers. Mutations in this gene are associated with paragangliomas and pheochromocytoma, linking mitochondrial dysfunction to tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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