Thermo Fisher Scientific ATG16L1 Polyclonal Antibody
Human ATG16L1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합하며 고순도(>95%) 항체입니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific ATG16L1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 93–137 of Human ATG16L1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803674 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Autophagy related protein 16L is encoded by the ATG16L gene located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10).
ATG12 and ATG5 conjugate with each other and oligomerize with ATG16L to form an 800 kDa Atg16L complex, which facilitates lipidation of LC3 to phosphatidylethanolamine (PE).
This ubiquitin-like conjugation system is a widely used marker for autophagy. The ATG16L complex, along with ATG18 and ATG21, prevents premature cleavage of ATG8-PE by the cysteine protease Atg4 until the autophagosome is complete.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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