Thermo Fisher Scientific Phospho-CYLD (Ser418) Polyclonal Antibody
CYLD 단백질의 Ser418 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin) 분석에 적합. 인간 및 랫트 시료 반응성. 1 mg/mL 농도의 액상 형태로, PBS/glycerol 버퍼에 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYLD (Accession Q9NQC7), corresponding to amino acid residues around phosphorylated Ser418. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816707 |
Product Specific Information
This antibody detects endogenous levels of CYLD only when phosphorylated at Ser418.
Target Information
CYLD is a 956 amino acid cytoplasmic deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family. It contains three CAP-GLY domains, a proline-rich region, an SH3 binding domain, and a catalytic domain homologous to UCH. CYLD functions as a tumor suppressor protein involved in the JNK signaling pathway and negatively regulates TRAF2 and NF-κB signaling. It also modulates the I-κB kinase pathway and exhibits deubiquitinating activity toward non-Lys-48-linked polyubiquitin chains. Mutations in CYLD are associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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