Thermo Fisher Scientific PSMA7 Monoclonal Antibody (OTI5F6), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended desalting column: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

PSMA7 is a component of the 20S core proteasome complex involved in proteolytic degradation of intracellular proteins.
It associates with regulatory particles to form the 26S proteasome, which participates in ATP-dependent degradation of ubiquitinated proteins, maintaining protein homeostasis by removing misfolded or damaged proteins.
When associated with PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation, essential for processes such as spermatogenesis and generation of MHC class I antigenic peptides.
PSMA7 also inhibits HIF-1A transactivation, enhances proteasome-mediated HIF-1A degradation under hypoxia, and plays a role in hepatitis C virus translation. Additionally, it mediates nuclear translocation of the androgen receptor (AR), enhancing androgen-mediated transactivation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.