Thermo Fisher Scientific ABCC5 (MRP5) Polyclonal Antibody
Thermo Fisher Scientific의 ABCC5 (MRP5) 폴리클로날 항체는 인간 단백질에 반응하며 WB 및 IHC에 사용 가능합니다. 합성 펩타이드로부터 제조되었으며, 동결건조 형태로 제공됩니다. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 10–60 of human ABCC5 conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ABCC5.
Target Information
The protein encoded by the ABCC5 (MRP5) gene belongs to the ATP-binding cassette (ABC) transporter superfamily. ABC proteins facilitate the transport of various molecules across cellular membranes and are categorized into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is part of the MRP subfamily, associated with multidrug resistance. It functions in the cellular export of cyclic nucleotides, contributing to their degradation and elimination. Studies indicate that ABCC5 confers resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. It may play a role in resistance mechanisms in acute lymphoblastic leukemia and HIV-infected patients. Alternative splicing has been observed, but complete sequence details remain unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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