Thermo Fisher Scientific Phospho-Ataxin 1 (Ser775) Polyclonal Antibody
Phospho-Ataxin 1 (Ser775) 특이적 인식 폴리클로날 항체로, 인간, 생쥐, 랫트 시료에 반응합니다. Western blot, IHC, ICC/IF 분석에 적합하며, 순차 크로마토그래피로 정제된 고순도 제품입니다. -20°C 보관, 연구용 전용입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATXN1 (Accession P54253), corresponding to amino acid residues around phosphorylated Ser775 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903062 |
Product Specific Information
This antibody detects endogenous levels of Ataxin 1 only when phosphorylated at Serine 775.
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I–III.
ADCAI is genetically heterogeneous, with five genetic loci (SCA1, 2, 3, 4, and 6) assigned to different chromosomes. ADCAII, associated with retinal degeneration (SCA7), and ADCAIII (SCA5) are more homogeneous.
ADCA is caused by expansion of CAG repeats, producing elongated polyglutamine tracts in the corresponding proteins. The diseased allele typically contains 41–81 CAG repeats (vs. 6–39 in normal alleles) and is associated with spinocerebellar ataxia type 1 (SCA1).
At least two transcript variants encoding the same protein have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-118560_Ataxin_1_P54253-1_Rabbit.svg, PA5-118560_Ataxin_1_P54253-1_Rabbit_PDP.jpeg)
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