Thermo Fisher Scientific Phospho-p130Cas (Tyr410) Polyclonal Antibody
인간 p130Cas의 Tyr410 인산화 부위에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 액상 형태이며 1 mg/mL 농도, -20°C 보관. 세포 부착 및 신호 전달 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human p130Cas around the phosphorylation site of Tyr410 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903064 |
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins.
It has a unique structure containing a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region.
p130Cas is implicated in various biological processes, including:
- Cell adhesion and migration
- Growth factor stimulation
- Cytokine receptor engagement
- Bacterial infection
Physiological functions include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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