Thermo Fisher Scientific ECD/SGT1 Monoclonal Antibody (PCRP-ECD-1D10)
ECD 단백질을 인식하는 Mouse monoclonal antibody로, Human 시료에 반응합니다. ICC, Flow, IP 등 다양한 응용에 사용 가능하며, Protein A/G로 정제된 액상형 제품입니다. p53 조절 및 세포주기 관련 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Immunoprecipitation (IP) | 1–2 µg/100–500 µg lysate |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-ECD-1D10 |
| Immunogen | Recombinant full-length human ECD protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: HeLa or 293T cells; human testis, spleen, or colon.
- Cellular Localization: Nucleus, Cytosol.
- Specificity Comments:
Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved in transcriptional regulation. In vitro, has intrinsic transactivation activity enhanced by EP300. May act as a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression and may disrupt Rb-E2F binding, leading to transcriptional activation of E2F proteins. The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May also play a role in regulation of pre-mRNA splicing. - Predicted Reactivity: Rabbit, Goat, Horse, Guinea pig, Dog, Pig, Rhesus monkey, Orangutan, Elephant (based on sequence homology).
Target Information
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53, possibly through cooperation with TXNIP. May participate in transcriptional regulation and act as a transcriptional activator for glycolytic genes. Plays a role in cell cycle progression and may disrupt Rb-E2F binding, leading to activation of E2F proteins. The regulatory function may depend on RUVBL1-mediated association with the R2TP complex. May also be involved in pre-mRNA splicing.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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