Thermo Fisher Scientific GFAP Polyclonal Antibody
GFAP 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간, 생쥐, 랫트 시료에서 Western blot, IHC, ICC 등에 사용 가능. 인간 GFAP 융합 단백질로부터 유래된 면역원 사용. 1 mg/mL 농도의 액상 형태이며, PBS buffer에 보존. 연구용 전용 제품.
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- PA19565
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:500–1:1,000 | 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:500–1:1,000 | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Human GFAP fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2109797 |
Product Specific Information
PA1-9565 detects GFAP in human, mouse, and rat samples.
It has been successfully used in Western blot, immunohistochemistry, and immunocytochemistry procedures.
The immunogen is a human GFAP fusion protein.
Target Information
GFAP (Glial fibrillary acidic protein) is a class III intermediate filament protein expressed in astrocytes and certain astroglia of the central nervous system, satellite cells of peripheral ganglia, and non-myelinating Schwann cells. Neural stem cells also express GFAP strongly.
Antibodies to GFAP are useful as markers of astrocytic cells and are expressed in various brain tumors derived from astrocytic cells. GFAP can also be found in lens epithelium, Kupffer cells of the liver, salivary tumors, and erythrocytes.
It is used to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.
Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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