Thermo Fisher Scientific CD263 (TRAIL-R3) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic Peptide: Y(24) S A T T A R Q E E V P(35) C

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2205073

Product Specific Information

PA1-956 detects decoy receptor 1 (DcR1) from human and rat tissues and cells.

PA1-956 has been successfully used in FACS and Western blot procedures. By Western blot, this antibody detects an ~30 kDa protein representing DcR1 from HEK293 cell lysate.

PA1-956 immunizing peptide corresponds to amino acid residues 24-35 of human DcR1. PA1-956 immunizing peptide (Cat. # PEP-047) is available for use in neutralization and control experiments.

Target Information

TRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.