Thermo Fisher Scientific RNASE3 Polyclonal Antibody
RNASE3 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 생쥐, 랫트 반응성 보유. Western Blot에 사용 가능하며, 항원 친화 크로마토그래피로 정제됨. PBS buffer에 0.05% sodium azide 포함, 4°C 또는 -20°C 보관.
- 카탈로그번호
- PA575363
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 130–160 of Human ECP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719091 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity >95% (by SDS-PAGE).
Target Information
ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein belonging to the pancreatic ribonuclease family.
ECP localizes to the granule matrix of eosinophils and plays a role in immune response. It acts as a cytotoxin, neurotoxin, and helminthotoxin secreted by activated human eosinophils, exhibiting anti-parasitic, antibacterial, and ribonucleolytic activities.
ECP is associated with the Gordon phenomenon, characterized by ataxia, muscular rigidity, paralysis, and tremor, and is considered a marker of eosinophilic inflammation. Elevated levels are observed in active asthma and allergic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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