Thermo Fisher Scientific beta Catenin Monoclonal Antibody (EM-22)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody reacts with the C-terminal part of beta-catenin (intracellular antigen), an 88 kDa multifunctional protein involved in both cell adhesion and activation of transcription.

Target Information

Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the formation and maintenance of epithelial layers by regulating cell growth and adhesion. Beta-catenin interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin, which anchors the complex to the cortical actin cytoskeleton.

Additionally, beta-catenin associates with complexes containing adenomatous polyposis coli (APC) protein and microtubules, interacting with signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless. These interactions regulate morphogenesis and cellular proliferation.

Beta-catenin is expressed in various hair follicle cells and epithelial structures. Aberrant beta-catenin activity is implicated in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors (breast, colon, liver, lung, gastric, prostate, skin). In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of cyclin D and c-myc, key regulators of cell proliferation and tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.