Thermo Fisher Scientific ZNF268 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:25–1:100

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total ZNF268 protein.

Target Information

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which involve transcriptional activation or repression.
Most zinc-finger proteins have a Krueppel-type DNA binding domain and a KRAB domain, which interacts with KAP1 to recruit histone-modifying proteins.
Zinc finger protein 268 (ZNF268), also known as zinc finger protein 3 or HZF3, is a 947 amino acid protein belonging to the Krueppel C2H2-type zinc-finger protein family.
ZNF268 contains 24 C2H2-type zinc fingers and one KRAB domain. Localized to the nucleus, ZNF268 is involved in transcriptional regulation and is highly expressed in three to five week old embryos.
ZNF268 has been implicated in human leukemia due to the identification of an alternatively spliced form in leukemia patients. Two named isoforms of ZNF268 exist as a result of alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.