Thermo Fisher Scientific FMO5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000
• Publications: -

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:200
• Publications: -

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total FMO5 protein.

Target Information

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans, resulting in a small subpopulation with reduced TMA N-oxidation capacity (fish odor syndrome, trimethylaminuria).
Three forms of the enzyme—FMO1 (fetal liver), FMO2 (adult liver), and FMO3—are encoded by genes clustered in the 1q23–q25 region.
Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyze oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.