Thermo Fisher Scientific VDP Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• PA1-006 detects p115 in rat and mouse samples.
• Successfully used in Western blot procedures.
• Detects a ~115 kDa protein representing p115 in rat and mouse liver samples.
• The immunogen sequence (M(1) N F L R G V M G G Q S A G P Q H(17)) is conserved across many species, including mouse and human.
• The immunizing peptide (Cat. # PEP-276) is available for neutralization and control experiments.

Target Information

This gene encodes a peripheral membrane protein that recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: the dephosphorylated protein associates with the Golgi membrane and dissociates upon phosphorylation. Ras-associated protein 1 recruits this protein to COPII vesicles during budding from the endoplasmic reticulum, where it interacts with COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GM130, and giantin sequentially.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.