Thermo Fisher Scientific alpha Dystroglycan Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 rabbit polyclonal alpha Dystroglycan 항체로 Western blot, IHC, ICC/IF, Flow cytometry에 적합. 1 mg/mL 농도의 액상 제품이며, PBS/BSA/glycerol buffer에 보존. 연구용으로 근육 및 신경계 단백질 분석에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human Alpha-dystroglycan aa 15–64 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890412 |
Target Information
Dystroglycan is a laminin-binding component of the dystrophin–glycoprotein complex, providing a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene associated with autosomal recessive muscular dystrophies. Reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to loss of linkage between the sarcolemma and extracellular matrix, increasing muscle fiber susceptibility to necrosis. It functions as a dual receptor for agrin and laminin-2 in Schwann cells. Muscle and nonmuscle isoforms differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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