Thermo Fisher Scientific Desmoglein 3 Polyclonal Antibody
Desmoglein 3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 세포 간 결합 및 pemphigus vulgaris 연구에 유용합니다.
- 카탈로그번호
- PA5114323
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human DSG3 (aa 709–897) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890437 |
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a desmosomal cadherin that plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium such as skin, oral mucosa, and esophagus. Dsg3 is the autoantigen of pemphigus vulgaris (PV), a severe autoimmune disease. Binding of anti-Dsg3 autoantibodies causes loss of cell adhesion, clinically resulting in blisters and histologically in suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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