Thermo Fisher Scientific CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), Super Bright 436, eBioscience

Thermo Fisher Scientific CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), Super Bright 436, eBioscience

Applications and Tested Dilution

Product Specifications

Available Conjugate Formats

• Unconjugated
• Alexa Fluor 532, 700
• APC, Biotin
• Brilliant UV 395, 615, 737, 805
• Brilliant Violet 421, 480, 605, 786
• eFluor 450, FITC
• NovaFluor Blue, Red, UV, Violet, Yellow series
• PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 600, 645, 702
• Custom conjugation available

Product Specific Information

The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185 (CXCR5/BLR1), a seven-transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma.
CD185 is expressed on B cells, CD4+ T cells (excluding Th1/Th2), and memory T cells (CD45RO+). It plays a key role in lymphocyte trafficking and T cell migration into B cell follicles in response to CXCL13, serving as a marker for follicular helper T cells.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-diluted, tested by flow cytometry on human peripheral blood cells; use 5 µL (1.0 µg) per test in 100 µL final volume.
Excitation/Emission: 405 nm / 436 nm (Violet laser)
Use a 450/50 bandpass filter or equivalent.

When using multiple Super Bright dye-conjugated antibodies, use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize non-specific polymer interactions.

Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.

Target Information

CXCR5 (CD185), also known as Burkitt lymphoma receptor 1 (BLR1), is a G protein-coupled receptor for chemokine BLC. It is expressed in lymphatic tissues such as lymph node follicles and spleen, playing an essential role in B cell migration.
CXCR5 expression has been observed in human blood, salivary gland, and various animal tissues. As a member of the GPCR family, CXCR5 shares the seven-transmembrane structure common to these receptors and participates in complex signaling and regulatory pathways relevant to pharmacological research.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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