Thermo Fisher Scientific CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), Super Bright 436, eBioscience
CD185(CXCR5) 단클론 항체(MU5UBEE)는 인간 및 비인간 영장류 시료에서 사용 가능한 Super Bright 436 형광 표지 항체입니다. Flow cytometry에 최적화되어 있으며, B세포 및 T세포 하위집단 분석에 활용됩니다. Violet laser(405 nm)로 여기되어 436 nm에서 방출됩니다.
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Thermo Fisher Scientific CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), Super Bright 436, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (1.0 µg)/test | View 7 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Rhesus monkey |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), Super Bright™ 436 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MU5UBEE |
| Immunogen | N-terminal extracellular domain of CXCR5 |
| Conjugate | Super Bright™ 436 |
| Excitation / Emission Max | 413 / 431 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724063 |
Available Conjugate Formats
- Unconjugated
- Alexa Fluor 532, 700
- APC, Biotin
- Brilliant UV 395, 615, 737, 805
- Brilliant Violet 421, 480, 605, 786
- eFluor 450, FITC
- NovaFluor Blue, Red, UV, Violet, Yellow series
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600, 645, 702
- Custom conjugation available
Product Specific Information
The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185 (CXCR5/BLR1), a seven-transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma.
CD185 is expressed on B cells, CD4+ T cells (excluding Th1/Th2), and memory T cells (CD45RO+). It plays a key role in lymphocyte trafficking and T cell migration into B cell follicles in response to CXCL13, serving as a marker for follicular helper T cells.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-diluted, tested by flow cytometry on human peripheral blood cells; use 5 µL (1.0 µg) per test in 100 µL final volume.
Excitation/Emission: 405 nm / 436 nm (Violet laser)
Use a 450/50 bandpass filter or equivalent.
When using multiple Super Bright dye-conjugated antibodies, use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize non-specific polymer interactions.
Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.
Target Information
CXCR5 (CD185), also known as Burkitt lymphoma receptor 1 (BLR1), is a G protein-coupled receptor for chemokine BLC. It is expressed in lymphatic tissues such as lymph node follicles and spleen, playing an essential role in B cell migration.
CXCR5 expression has been observed in human blood, salivary gland, and various animal tissues. As a member of the GPCR family, CXCR5 shares the seven-transmembrane structure common to these receptors and participates in complex signaling and regulatory pathways relevant to pharmacological research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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