Thermo Fisher Scientific IL-13 Monoclonal Antibody (JES10-5A2)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

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Immunohistochemistry (IHC)

Assay-dependent

-

Flow Cytometry (Flow)

Assay-dependent

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ELISA (ELISA)

Assay-dependent

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Neutralization (Neu)

Assay-dependent

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Miscellaneous PubMed (Misc)

-

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Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

JES10-5A2

Immunogen

Purified recombinant human IL-13

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

purified

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C

RRID

AB_2536246

Target Information

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.