Thermo Fisher Scientific IL-1 alpha Monoclonal Antibody (840C20B8), Biotin

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

This product is recommended as a detection antibody in Sandwich ELISA applications.

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both shared with IL-1 beta.
Located on chromosome 2q13, IL-1 alpha plays a key role in innate host defense by inducing proinflammatory cytokine production and acute-phase responses.
Its activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which inhibits receptor binding competitively.

IL-1 alpha participates in immune responses, inflammation, and hematopoiesis. It is produced as a proprotein by monocytes and macrophages, processed upon cell injury, and can induce apoptosis.
The IL1A gene forms part of a cytokine gene cluster on chromosome 2, affecting NF-kappaB and MAPK pathways. IL-1 alpha also stimulates IL6 and COX-2 (PTGS2) expression and enhances nitric oxide (NO) production.
Elevated IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.