Thermo Fisher Scientific FGFR-1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human FGFR-1 for IHC applications. High specificity and affinity purified by antigen chromatography. Suitable for research in cancer and developmental biology. Supplied in liquid form with stabilizer for reliable st...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 2–10 µg/mL
Publications: [References available upon request]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from internal sequence of human FGFR-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma
- Cellular location: Cytoplasmic, membrane
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are high-affinity receptors for 17 growth factors (FGF1–17). These receptors play key roles in mesoderm induction, patterning, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, generating multiple variants expressed during embryonic and adult stages. Mutations or defects in FGFR1 are associated with several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 have been linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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