Thermo Fisher Scientific Cyclin G1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: MCF7
• Cellular location: Nuclear

Target Information

Cyclins are regulatory subunits of Cdc2 p34 and related cyclin-dependent kinases (Cdks), which play key roles in controlling cell cycle progression.

• Cyclin A and B form complexes with Cdc2 p34 kinase to regulate G2–M and S phase transitions.
• G1–S transition is controlled by G1 cyclins such as Cyclin D1, which associates with Cdk2, Cdk4, and Cdk5.
• Cyclin E interacts with Cdk2 during the G1–S transition.
• Cyclin G contains an N-terminal cyclin box and a C-terminal domain homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor.
• Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated without apparent cell cycle dependency.
• Cyclin G2 shares 53% sequence identity with Cyclin G1, with peak expression in late S phase, whereas Cyclin G1 expression is constitutive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.